Genetic Factors of Autoimmune Diseases

Genetic Factors of Autoimmune Diseases 2017

Genetic Factors of Autoimmune Thyroid Diseases in Japanese

Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are caused by immune response to self-thyroid antigens and affect approximately 2-5% of the general population. Genetic susceptibility in combination with external factors, such as smoking, viral/bacterial infection, and chemicals, is believed to initiate the autoimmune response against thyroid...

Transcription factors in autoimmune diseases.

Studies on the pathogenesis of autoimmune diseases have begun to delve into the molecular and cellular mechanisms, and transcription factors, as key regulators of immune effector cell development and function, have received growing attention. Their involvement has been investigated in immune cells, such as T and B lymphocytes, macrophages and neutrophils, but also end-organ tissues, such as syn...

The mosaic of autoimmunity: genetic factors involved in autoimmune diseases--2008.

Genetic Factors in Autoimmune Diseases Thirty years ago we referred to the “Mosaic of Autoimmunity” [1] as the combination of factors associated with the induction of autoimmune diseases. We classified the factors as genetic, immune, hormonal, and environmental. For a specific autoimmune condition to develop, a particular combination of these factors (like the pebbles or small pieces of glass o...

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...